The metabolic anatomy of Parkinson's disease: Complementary [18F]fluorodeoxyglucose and [18F]fluorodopa positron emission tomographic studies
Identifieur interne : 002750 ( Main/Exploration ); précédent : 002749; suivant : 002751The metabolic anatomy of Parkinson's disease: Complementary [18F]fluorodeoxyglucose and [18F]fluorodopa positron emission tomographic studies
Auteurs : Eidelberg [États-Unis] ; Moeller [États-Unis] ; V. Dhawan [États-Unis] ; Sidtis [États-Unis] ; J. Z. Ginos [États-Unis] ; Strother [États-Unis] ; J. Cedarbaum [États-Unis] ; P. Greene [États-Unis] ; S. Fahn [États-Unis] ; Rottenberg [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1990.
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Abstract
We studied the metabolic anatomy of typical Parkinson's disease (PD) using [18F]fluorodeoxyglucose (FDG) and [18F]fluorodopa (FDOPA) and positron emission tomography (PET). Fourteen PD patients (mean age 49 years) had FDG/PET scans, of which 11 were scanned with both FDOPA and FDG. After the injection of FDOPA, brain uptake and arterial plasma radioactivity were monitored for 2 h. Striatal FDOPA uptake was analyzed with regard to a two‐compartment model, and target‐to‐background ratios (TBRs) and TBR‐versus‐time slopes were also calculated. Regional patterns of metabolic covariation were extracted from FDG/PET data using the Scaled Subprofile Model (SSM). SSM pattern weights, FDOPA uptake constants (Ki), TBRs, and TBR slopes were correlated with clinical measures for bradykinesia, rigidity, tremor, gait disturbance, left‐right asymmetry, dementia, and overall disease severity. In PD patients, rate constants for FDOPA uptake correlated with individual measures of bradykinesia (p = 0.001) and gait disability (p < 0.05). SSM analysis revealed a distinct pattern of regional metabolic asymmetries, which correlated with motor asymmetries (p < 0.001) and left‐right differences in Ki (p < 0.01). Our data suggest that in PD patients, FDG/PET and FDOPA/PET may provide unique and complementary information about underlying disease processes.
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DOI: 10.1002/mds.870050304
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Cedarbaum</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Memorial Sloan‐Kettering Cancer Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Burke Rehabilitation Hospital, White Plains, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Greene, P" sort="Greene, P" uniqKey="Greene P" first="P." last="Greene">P. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1990">1990</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="203">203</biblScope><biblScope unit="page" to="213">213</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">606D339996D4D4548BEABEE9FC8966E0BAF459A0</idno><idno type="DOI">10.1002/mds.870050304</idno><idno type="ArticleID">MDS870050304</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Metabolic anatomy</term><term>Parkinson's disease</term><term>Positron emission tomography</term><term>[18F]Fluorodeoxyglucose</term><term>[18F]Fluorodopa</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the metabolic anatomy of typical Parkinson's disease (PD) using [18F]fluorodeoxyglucose (FDG) and [18F]fluorodopa (FDOPA) and positron emission tomography (PET). Fourteen PD patients (mean age 49 years) had FDG/PET scans, of which 11 were scanned with both FDOPA and FDG. After the injection of FDOPA, brain uptake and arterial plasma radioactivity were monitored for 2 h. Striatal FDOPA uptake was analyzed with regard to a two‐compartment model, and target‐to‐background ratios (TBRs) and TBR‐versus‐time slopes were also calculated. Regional patterns of metabolic covariation were extracted from FDG/PET data using the Scaled Subprofile Model (SSM). SSM pattern weights, FDOPA uptake constants (Ki), TBRs, and TBR slopes were correlated with clinical measures for bradykinesia, rigidity, tremor, gait disturbance, left‐right asymmetry, dementia, and overall disease severity. In PD patients, rate constants for FDOPA uptake correlated with individual measures of bradykinesia (p = 0.001) and gait disability (p < 0.05). SSM analysis revealed a distinct pattern of regional metabolic asymmetries, which correlated with motor asymmetries (p < 0.001) and left‐right differences in Ki (p < 0.01). Our data suggest that in PD patients, FDG/PET and FDOPA/PET may provide unique and complementary information about underlying disease processes.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Eidelberg" sort="Eidelberg" uniqKey="Eidelberg" last="Eidelberg">Eidelberg</name></region><name sortKey="Cedarbaum, J" sort="Cedarbaum, J" uniqKey="Cedarbaum J" first="J." last="Cedarbaum">J. Cedarbaum</name><name sortKey="Cedarbaum, J" sort="Cedarbaum, J" uniqKey="Cedarbaum J" first="J." last="Cedarbaum">J. Cedarbaum</name><name sortKey="Dhawan, V" sort="Dhawan, V" uniqKey="Dhawan V" first="V." last="Dhawan">V. Dhawan</name><name sortKey="Dhawan, V" sort="Dhawan, V" uniqKey="Dhawan V" first="V." last="Dhawan">V. Dhawan</name><name sortKey="Dhawan, V" sort="Dhawan, V" uniqKey="Dhawan V" first="V." last="Dhawan">V. Dhawan</name><name sortKey="Eidelberg" sort="Eidelberg" uniqKey="Eidelberg" last="Eidelberg">Eidelberg</name><name sortKey="Eidelberg" sort="Eidelberg" uniqKey="Eidelberg" last="Eidelberg">Eidelberg</name><name sortKey="Fahn, S" sort="Fahn, S" uniqKey="Fahn S" first="S." last="Fahn">S. Fahn</name><name sortKey="Ginos, J Z" sort="Ginos, J Z" uniqKey="Ginos J" first="J. Z." last="Ginos">J. Z. Ginos</name><name sortKey="Ginos, J Z" sort="Ginos, J Z" uniqKey="Ginos J" first="J. Z." last="Ginos">J. Z. Ginos</name><name sortKey="Greene, P" sort="Greene, P" uniqKey="Greene P" first="P." last="Greene">P. Greene</name><name sortKey="Moeller" sort="Moeller" uniqKey="Moeller" last="Moeller">Moeller</name><name sortKey="Moeller" sort="Moeller" uniqKey="Moeller" last="Moeller">Moeller</name><name sortKey="Rottenberg" sort="Rottenberg" uniqKey="Rottenberg" last="Rottenberg">Rottenberg</name><name sortKey="Rottenberg" sort="Rottenberg" uniqKey="Rottenberg" last="Rottenberg">Rottenberg</name><name sortKey="Rottenberg" sort="Rottenberg" uniqKey="Rottenberg" last="Rottenberg">Rottenberg</name><name sortKey="Sidtis" sort="Sidtis" uniqKey="Sidtis" last="Sidtis">Sidtis</name><name sortKey="Sidtis" sort="Sidtis" uniqKey="Sidtis" last="Sidtis">Sidtis</name><name sortKey="Sidtis" sort="Sidtis" uniqKey="Sidtis" last="Sidtis">Sidtis</name><name sortKey="Strother" sort="Strother" uniqKey="Strother" last="Strother">Strother</name><name sortKey="Strother" sort="Strother" uniqKey="Strother" last="Strother">Strother</name><name sortKey="Strother" sort="Strother" uniqKey="Strother" last="Strother">Strother</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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